E3NET ?
E3Net is a web-based system that provides a comprehensive collection of available E3-substrate specificities and a systematic framework for the analysis of E3-mediated regulatory networks of diverse cellular functions. Currently, E3Net contains 2201 E3s and 4896 substrates in 427 organisms, and 1671 E3-substrate specific relations between 493 E3s and 1277 substrates in 42 organisms, extracted mainly from MEDLINE abstracts and UniProt comments with an automatic text mining method and additional manual inspection, and partly from high-throughput experiment data and public ubiquitination databases. The significant functions and pathways of the extracted E3-specific substrate groups were identified from a functional enrichment analysis with 12 functional category resources for molecular functions, protein families, protein complexes, pathways, cellular processes, cellular localization, and diseases. E3Net includes interactive analysis and navigation tools that make it possible to build an integrative view of E3-substrate networks and their correlated functions with graphical illustrations and summarized descriptions.
Citing E3Net
Han Y, Lee H, Park JC, Yi GS (2012) E3Net: a system for exploring E3-mediated regulatory networks of cellular functions. Mol Cell Proteomics. 11(4):O111.014076 [PMID:22199232]
Download E3-substrate Relations: click here
WHAT WE PROVIDE
  • Browsing and text-search interface for E3s and substrates
  • Supports various types of input queries
    • UniProt ID/AC
    • Protein/gene name
    • E3 type (subunit composition and domain subclass)
    • NCBI taxonomy ID/name
  • Browsing and text-search interface for function terms
  • Supports various types of input queries
    • Term ID/name
    • NCBI taxonomy ID/name
STATISTICS: # OF E3 LIGASES AND SUBSTRATES (by organism)
Statisics for all E3s and substrates collected in our database
CATEGORY
HUMAN
MOUSE
YEAST
TOTAL
E3
SUBSTRATE
STATISTICS: # OF E3 LIGASES (by E3 type and organism)
Statistics for E3s having one or more specific substrates in our database
E3 SUBUNIT COMPOSITION
E3 FAMILY
HUMAN
MOUSE
YEAST
TOTAL
SINGLE-SUBUNIT E3
HECT
RING
UBOX
ETC.
MULTI-SUBUNIT E3
HECT
RING
TOTAL